Teratogenic Effects - Pregnancy Category C Select one or more newsletters to continue. WebPromethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. MeSH Keep this medication in the carton or container it came in, tightly closed, and out of reach of children. It is used to help motion sickness . Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. R)EU4u:/uug83YR/^dL P?062v*6>As5>) ,]'bHK80Ume4xWTJy$yI p7[I?ruO[P8kW,]6-tg4IE&()LV l=-V4{d]|O tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Respiratory rate, especially in pediatric patients. An official website of the United States government. Parenteral: 12.5 mg IM or IV once, and may be repeated within 2 hours if necessary Generic alternatives may be available. Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl (see Throw away unused or expired drugs. Promethazine HCl Suppositories should be used with caution in pediatric patients 2 years of age and older (see These results suggest that in conscious rats many factors such as a locomotor hyperactivity and enhancement of gastrointestinal motility caused by the rectal administration mask the real character of suppositories. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. Would you like email updates of new search results? Presence in Breast Milk, Medline Plus, Oral formulations are preferred; however, rectal or parenteral formulations may be given if oral formulations are not tolerated. Promethazine HCl Suppositories administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. Allergic conjunctivitis due to inhalant allergens and foods, Amelioration of allergic reactions to blood or plasma, In anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, Mild, uncomplicated allergic skin manifestations of urticaria and angioedema, Other uncomplicated allergic condition of the immediate type when oral therapy is impossible or contraindicated, Early stages of labor: 50 mg IM or IV once, Nighttime sedation: 25 to 50 mg IM or IV once. <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S>> endobj Attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilation. Copy the URL below and paste it into your RSS Reader application. Control) Pramlintide injection (Symlin) Promethazine suppositories (Promethegan) Proparacaine ophthalmic. Administered IV as an adjunct to anesthesia or analgesia with reduced amounts of meperidine of other narcotic analgesics in special surgical situations (e.g., repeated bronchoscopy, ophthalmic surgery, poor-risk patients), Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. Glucose Tolerance Test (See 1990 Apr;38(4):1027-31. doi: 10.1248/cpb.38.1027. Promethazine HCl is a racemic compound; the empirical formula is C 17 H 20 N 2 SHCl and its molecular weight is 320.88. PROMETHEGAN (Cosette Pharmaceuticals, Inc.): FDA Package This report on medications is for your information only, and is not considered individual patient advice. WARNINGS Use in Pediatric Patients). The photolytic degradation of promethazine hydrochloride does not follow simple first-order kinetics. For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated. Oral or Rectal: 6.25 to 12.5 mg orally or rectally before meals and at bedtime, as necessary OR 25 mg orally or rectally once a day at bedtime Promethazine HCl Suppositories are contraindicated for use in pediatric patients less than two years of age. Maximum dose: 25 photolytic degradation studies of promethazine Federal government websites often end in .gov or .mil. Citations, PRECAUTIONS- Information for Patients and Drug Interactions, Carcinogenesis, Mutagenesis, Impairment of Fertility, Report Adverse Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities. The stability of aqueous solutions of promethazine hydrochloride as a function of pH. Last updated on Apr 10, 2023. Subsequent doses on succeeding days of travel should be given on rising and again before the evening meal. Is NDC 0713-0526 included in the NDC Directory? Only in cases of extreme overdosage or individual sensitivity do vital signs, including respiration, pulse, blood pressure, temperature, and EKG, need to be monitored. Patients should be told to report any involuntary muscle movements. Dermatologic Dermatitis, photosensitivity, urticaria. 2 SHCl and its molecular weight is 320.88. 2. HAZARDS IDENTIFICATION Dermographism. , 4500 East-West Highway, Suite 900, Bethesda, Maryland. Brand name: Phenergan The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. https://medlibrary.org/lib/rx/meds/promethegan-5/. You may also report side effects at https://www.fda.gov/medwatch. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment FOIA It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Limited experience with dialysis indicates that it is not helpful. 65 years and older: Elderly patients should be given lower initial doses and should be closely monitored for adverse events. breathing. This possibility should be considered with Promethazine HCl Suppositories. PRECAUTIONS- Information for Patients and Drug Interactions). drugs that can do this.