Daptomycin RF has a longer in-use shelf period although times vary based on dosage form (vial, IV bag, or syringe) and diluent used. With our easy-to-use reconstitution calculator, you now dont have to worry about all the multiplication, division or the unit conversion and all. Wir verstehen die Bedeutung der Kunden auf dem richtigen Weg zum Erfolg bringen, und wir sind bereit, mit ihnen der Planung in allen Bereichen zu arbeiten. Unlike a powder or liquid fill, a low fill would not be readily apparent after lyophilization. Nothing really. See WARNINGS, PRECAUTIONS Dosage form: injection, solution The next step is to do is add the mass of the peptide in mg that you want to reconstitute (This is generally going to be listed on the peptide vial) with the x ml of bacteriostatic water in order to get your desirable dosage in mcg. Adverse reactions are rare and can include fever, infection, and thrombosis. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. Good practice and a good quality assurance program would include the frequent monitoring of the volume of fill such as every 15 minutes. Water balance is maintained by various regulatory mechanisms. Due to the bacteriostat, bacteriostatic water comes in a multi-dose formulation for multiple uses. Reconstitution. You may report side effects to FDA at 1-800-FDA-1088. Now here comes the crux of the article after talking about some of the major prerequisites of the peptide reconstitution process. False Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. Both are suitable for subcutaneous intravenous, intramuscular, and intradermal injections. Click to reveal Handlers should follow the applicable dosage and administration schedule [16]. Mrose . It is used as a solvent or dilutant for drugs or therapeutic compounds that call for aqueous injection. Sterile water is free of any organic materials but contains inorganic materials to some extent. (I would personally recommend bacteriostatic water because of its longer shelf-life). There is no sort of preservative or antimicrobial agent added to it. Bacteriostatic Water vs. Sterile Water | Deus Medical You hereby indemnify to the fullest extent Buckle LLC from and against any and/or all liabilities, costs, demands, causes of action, damages and expenses arising in any way related to your breach of any of the provisions of these Terms. Sterile water is purified water that has been distilled and brought to a pH between 5.0 to 7.0. Side Effects of Bacteriostatic Water (Bacteriostatic Water for - RxList Please enter the email address for your account. Bacteriostatic water is usually the term given to a commercial preparation (made by Hospira, for example), whereas reconstitution solution is the term given by a smaller (usually underground) company that makes its own to sell. Parenteral drug products should be inspected visually for particulate matter Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! Carefully install the needle tip on a syringe. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. RxList does not provide medical advice, diagnosis or treatment. To really know the best solvent in which a peptide will be soluble, you must have to consider some biochemistry knowledge and do some trial and error. Stability data should be reviewed and the justification of the expiration date should be based on batches with the higher moisture content. These are the primary similarities between bacteriostatic water and sterile water [5]: Here are the key differences between bacteriostatic water and sterile water [5]: Despite their similarities, bacteriostatic water and sterile water differ in a few key areas. You can go as high as 2 milliliters per peptide reconstitution as it does no harm other than more dilution. Bacteriostatic Water for Peptides | Learn How to Prepare Bacteriostatic Any user ID and password you may have for this Website are confidential and you must maintain confidentiality as well. This can come into play when preparing for traveling, budgeting monthly expenses and storage. Data are unavailable on the toxicity of other preservatives in this age group. Because of the potential toxicities associated with Bacteriostatic Water for Injection, many hospitals only utilize WFI. What is the difference between bacteriostatic water and sterile water By using this Website, you agreed to accept all terms and conditions written in here. ITG SUBJECT: LYOPHILIZATION OF PARENTERALS. It is also not known whether Bacteriostatic Water for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Performance & security by Cloudflare. Before digging deeper into precise conditions required to store peptides, you should know that keeping a peptide vial away from intense light, high temperature and moisture is a MUST. It is also not known whether Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Bacteriostatic Water Vs. Sterile Water Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. FDA rev date: 6/15/2000. Drug class: Sterile irrigating solutions. This information, including any referenced scientific or clinical research, is made available for educational purposes only. SIDE EFFECTS. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Both meet US Pharmacopeia (USP) standards. In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. Bacteriostatic Water may cause serious side effects including: Get medical help right away, if you have any of the symptoms listed above. Researchers also use organic solvent such as Acetic acid and DMSO to dissolve hydrophobic peptides and polar uncharged amino acids. You must not use this Website if you disagree with any of these Website Standard Terms and Conditions. Using either in the proper conditions can provide extraordinary results. The most common side effects of H2Oinclude: Tell the doctor if you have any side effect that bothers you or that does not go away. Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. It is a copolymer of ethylene and propylene. Peptide Reconstitution: Dosing, Mixing and Storage Guidelines When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. As defined in Section 10.01. The very first step is pick the syringe size that you have purchased. Reconstitution follows the above method. Buckle LLC reserves the right to remove any of Your Content from this Website at any time without notice. This method can preserve the peptides stability and activity for several months to years, depending on the peptides properties and storage conditions. Bacteriostatic Water for Injection may kill some of the vegetative cells if present as contaminants. did you ever get an answer? This solution has no antimicrobial agents. Exogenous formulations are available in powder and liquid forms. Both act as dilutants or solvents of substances to enable injection. Your IP: Peptides the proteins little brother can do wonders for our bodies! SOLU-CORTEF Dosage and Administration (hydrocortisone sodium succinate