Thanks so much in advance for any feedback. I paid a fortune for those sessions (I dont have insurance). Overall, I really wish clinics and REs were more straightforward about odds of success esp with pgs since I think they can be a little misleading. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. I honestly wish I had but thats all hindsight now knowing what I knew. How fast embryos grow has an impact on success rates for untested embryos. I know Im shocked this was never brought up by my doctor, after everything. PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. Alternatively you can check out my websites tag for mosaic embryos here. With both transfers I did estrogen tablets, progesterone in oil shots, blood thinner shots and low dose aspirin. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. About 7 months later I transferred a day 7. Find advice, support and good company (and some stuff just for fun). I did acupuncture that cycle. We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. Note that this paper is still preprint as of Nov 2021. But after this chemical pregnancy from our PGS embryo, I have a gut feeling there is something else at play and am pushing my doctor for additional testing before another transfer since we only have 3 embryos left after 2 IVF cycles. I have had my heart broken multiple times. Thanks for sharing your story because it does give me hope! I know how hard this all is. If you did PGS after multiple miscarriages and failed attempts how many did you transfer? Some of the issues with the studies included in the meta-analysis were brought up: Future studies should focus on single embryo transfers, and in women >35, to see if PGT-A truly has a reduction in miscarriage rates for this age group. Thankful for these forums! I only have embryo left ugh . It is seriously invaluable to me. A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. Did testing and just found out it was a triploid embryo so it had 69 chromosomes. Once they see it on an U/S, I think it becomes a clinical pregnancy. I did PGS testing. How does anyone not go completely crazy through this whole process???? MENTS our next transfer was successful and I'm coming up on 12 weeks. I will look into this and mention to my doctor :) Ive been taking 10mg of prednisone but Ive never taken Lovenex. Some are faster, and some are slower. I am remaining hopeful, when we sent our embryos for testing, they only thought that one would come back normal. For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. Only one normal PGS embryo - any advice on preparing for - Inspire The test uses an algorythm and brings together age (in my case 44), the nuchal measurement of the foetus (which was normal) and the values of PAPP-A and Beta HCG from a blood test. Chemical pregnancy with PGS-tested embryo - Ask the RE As for boosting chances with two put back it should not be the trick. Does this harm the embryo or reduce its potential for success? What are the differences between the two tests? Statistically speaking it takes an average of two transfers before a successful pregnancy. Aneuploids on the other hand, at least based on 1 study, seem to have a 100% miscarriage rate. You can check out my summary of the study here. A genetically normal embryo has a 70% chance of a positive pregnancy test in any woman, whether she is 20 years old or 40 years old. So weve been ttc for almost 2 years. I'm in a similar situation so will ask my RE about all of this! We got to see and hear the heartbeat yesterday. MENTS THROUGHOUT MENTS Did your doctor have your SO go through the rounds of antibiotics as well? Live birth rate differences are inconsistent and therefore inconclusive. 2005-2023Everyday Health, Inc., a Ziff Davis company. There was a greater reduction in the >35 group (10.4% for PGT-A vs 27.9% for untested) compared to the <35 group (13.3% for PGT-A vs 16.1% for untested), however neither of these analyses were statistically significant. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. I asked her can we do bloodwork to see what couldve caused the miscarriage (I.e immune complex, blood clotting disorder or inflammation) and she doesnt think I need to and how we should proceed with the same protocol again and I dont know how to feel about this unable to sleep. And demand that my lining be over 8 before I allow another transfer to occur? To do PGT-A, a sample of cells (a biopsy) is taken from the embryo and is submitted for DNA testing in a separate lab. 2014). If you have any questions about my protocol happy to answer. I just don't know what to do. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. Meaning that if you begin a cycle, retrieve eggs, produce embryos, then do PGS testing, and at least one embryo comes back normal, 60 - 70% of the time it will lead to a live birth. Existing data show that the live birth rate is between 60-80% when a single frozen embryo is transferred in a second cycle.