Sci. (n.d.). Drug Deliv. They point to the fact that just because a material is nanosized, it does not mean it is dangerous, indeed. Diverse biomolecules can constitute a ligand, including antibodies, proteins, nucleic acids, peptides, carbohydrates and small organic molecules such as vitamins [43,44,45]. Apart from folate-mediated targeting, aptamer-functionalized PEG-PLGA nanoparticles have also been constructed for anti-glioma drug delivery by active targeting the tumor. Biomed. Nanoparticles for Cancer Therapy: Current Progress and Challenges The accumulation of the nanocarriers is essentiallydepends on physicochemical properties such as size, shape (morphology), surface charge and surface chemistry [32]. 353(1), 2632 (2007), F. Zhao et al., Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Nanotechnol. 133(44), 1756017563 (2011), Y.Y. Theranostics 8(3), 693709 (2018), G. Wang et al., Theranostic hyaluronic acid-iron micellar nanoparticles for magnetic-field-enhanced in vivo cancer chemotherapy. Moreover, the studies of Villanueva et al. Xia et al., constructed a pH sensitive liposome formulation by loading tariquidar (TQR) and doxorubicin to overcome multidrug resistance of drug-resistant ovarian cancer cells. Cells were incubated for 48h and BCL-2 siRNA concentration used is 20nM (c); Mean tumor volume determined using magnetic resonance imaging measured after 25days of the first injection. Mater. Additionally, a newer generation of liposomes are emerging, focusing on redox sensitive liposomes, magnetic liposomes, enzyme sensitive liposomes and multifunctional smart liposomes [242,243,244,245]. Several studies have demonstrated enhanced antitumor activity with targeting moieties. Drug Deliv. 2020 Dec 15;591:119986. doi: 10.1016/j.ijpharm.2020.119986. 2023 Mar 23;14:1121950. doi: 10.3389/fphar.2023.1121950. 3, 303312 (2005), Q. Liu et al., Differentiation of cancer cell type and phenotype using quantum dot-gold nanoparticle sensor arrays. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. Several researchers have demonstrated that half-generation dendrimers exhibit lower toxicity than the full generation of polyamide amine [277,278,279]. 15(6), 21942205 (2018), M.U. Cells Nanomed. The delivery of PEGylated multi-walled carbon nanotubes conjugated with doxorubicin efficiently released 57% of the drug at lower pH within 24h, and could inhibit HepG2 cells when compared to free doxorubicin [204]. Ghaffari et al., Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment. In another study, resveratrol encapsulated PLGA [poly(lactic-co-glycolic acid)] nanoparticles have been constructed for prostate cancer therapy. Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance. Acta 1806(1), 2935 (2010), J.T. 66, 225 (2014), D. Rosenblum et al., Progress and challenges towards targeted delivery of cancer therapeutics. Additionally, as new multidrug resistance mechanisms are unraveled and studied, nanoparticles are being investigated more vigorously. 127(36), 1249212493 (2005), Z. Liu et al., Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Carbohyd. Correspondingly, these vehicles offer several other advantages including biocompatibility, self-assembly, and high drug cargo loading [231]. Yadav, S.C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems. ACS Nano 3(2), 307316 (2009), S.R. Int. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Furthermore, the manufacturing of nanomedicine products for commercialization is a key obstacle, as large scale-production is technically challenging. 202, 513522 (2018), V.M. ACS Nano 6(6), 53665380 (2012). Adv. The nanoformulation exhibited a high rate of apoptosis against human liver cells and stronger anti-angiogenic effects together with inhibition of proliferation, migration, invasion, and tube formation [272]. 42, 232246 (2016), C. Gao et al., pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate. They have an ultra-small size, large . Photobiol. This important study signposts the strategy of modifying the surface of liposomes for effective delivery of anticancer drugs to treat hepatocellular carcinoma [235]. 107, 11501158 (2019), W. Zheng et al., Encapsulation of verapamil and doxorubicin by MPEG-PLA to reverse drug resistance in ovarian cancer. HHS Vulnerability Disclosure, Help J. Nanotechnology enabling the use of circulating tumor cells (CTCs) as reliable cancer biomarkers. B Biol. Biol. Chem. Int. Mol. have used benzoic-imine bonds to attach -cyclodextrin directly to mesoporous silica nanoparticles (MSNs) which were partially hydrolyzed in the extracellular tumor space and completely hydrolysed inside endosomes with low pH ~5. P. N. Navya or Hemant Kumar Daima. c The in vitro influence of IGF1 and IGF1-IONPs on cell proliferation. Nanomedicine 5(10), 15351546 (2010), T. Feng et al., Charge-convertible carbon dots for imaging-guided drug delivery with enhanced in vivo cancer therapeutic efficiency. Mater. Release 172(3), 852861 (2013), S.K. Would you like email updates of new search results? Generally, only small quantities of nanomedicine are used for pre-clinical and clinical trial studies. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Cancer Res. The effectiveness of anticancer drug treatment can be achieved only when the administered drug is of proper dosage and display maximal activity in the cancer cells. B 3(39), 77247733 (2015), J. Zhang et al., pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. approaches in cancer treatment are (a) Surgical excision, (b) Irradiation and (c) Chemotherapy. Rev. Release 172(3), 782794 (2013), C. Wong et al., Multistage nanoparticle delivery system for deep penetration into tumor tissue. PMC Bioconjug. 2023 Mar 25;11(4):733. doi: 10.3390/vaccines11040733. Drug Deliv. 8d, e was determined by magnetic resonance imaging and showed that temozolomide and siRNA conjugated nanocomplex had a volume of 8211mm3 which is much less than the volume resulting with the other treatments. 2018 Feb 1;125:1-2. doi: 10.1016/j.addr.2018.04.014. J. Nanomed. The nanosystems exhibited higher internalization degree into human osteosarcoma cells and induced almost 100% osteosarcoma cell death with a low doxorubicin loading of 2.5g/mL. a The effect of IGF1R in MIAPaCa-2 cells was assessed by immunofluorescence labeling employing an anti-IGF1R antibody (shown in red color). Here, the size and size-dependent properties of the material will be the key to improving penetration into the matrix. Better diagnostics. Interfaces 9(46), 4088740897 (2017), Y. Tang et al., Co-delivery of trichosanthin and albendazole by nano-self-assembly for overcoming tumor multidrug-resistance and metastasis. According to the World Health Organization, cancer is the second leading cause of death worldwide, accounting for 9.6 million deaths in 2018 [].The global efforts in cancer prevention, early diagnosis, screening and treatment, have been challenged by the complexity and variability of tumors (reviewed in []).The genomic instability of tumor cells and a pro-inflammatory . Int. Researchers at Stanford University recently have been developing nanotechnologies that give both anatomical size and location of prostate cancer cells (nanobubbles for ultrasound imaging) and functional information to avoid overdiagnosis/treatment as well as to monitor progression (self-assemblying nanoparticles for photoacoustic imaging). Nat. Specificity is defined as how effective the interaction is between the ligand-conjugated nanoparticles with their target molecules weighted against off-target effects incurred before reaching the target molecules. All these strategies can reduce the systemic toxicity at the tumor sites by ensuring that healthy cells are not affected. Adv. CAS This alteration could cause nanoparticles to lose their specificity leading to sub-optimal localization in desired sites or at cellular targets. Interfaces 10, 2116021172 (2018), N. Guldris et al., Orthogonal clickable iron oxide nanoparticle platform for targeting, imaging, and on-demand release. Effect of OVA-iron oxide nanoparticles: macrophages activation with different concentrations of OVA, and production of a TNF-, b IL-6, c IFN-. J. Healthc. Jeong, S. Jon, A drug-loaded aptamergold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. Nanomaterials used in cancer therapy can be classified into several main . The first FDA (the Food and Drug Administration, national agency of the United States Department of Health and Human Services) approved nano-drug is one consisting of PEGylated liposome entrapped doxorubicin (DOX) targeted against HIV-related Kaposi sarcoma tumor, and ovarian cancer. Mater. PubMedGoogle Scholar. Polym. VR acknowledges the NIH (EB022641). In one study, anti-HER2 targeting ligand moieties functionalized on the surface of liposome increased the cellular uptake of the nanoparticles in HER2-expressing cancer cells. Biotechnol. The in vitro magnetic resonance imaging confirmed the enhanced binding and accumulation of iron oxide nanoparticles in PC-3 cells, when compared with normal prostate epithelial cells. 8600 Rockville Pike J. Biochem. Nanotechnology is expected to be promising in many fields of medical applications, mainly in cancer treatment. Clipboard, Search History, and several other advanced features are temporarily unavailable. Park W, Heo YJ, Han DK. Chem. The outcomes of the study are promising and recommend a topical nanoformulation to enhance drug efficacy against skin cancer. Also, it is apparent that the nanomaterials distribution within the cell is strongly governed by their surface charge, which needs to be engineered to avoid undesirable uptake from the normal cells to achieve target specific action without adverse impact on normal cells. Various nanoformulations including polymeric, liposomes, and lipid-polymer hybrid nanoparticles have already been proposed to improve the biodistribution and targeting capabilities . Epub 2015 Mar 23. Int. 2023 Mar 27;15(3):393-409. doi: 10.4254/wjh.v15.i3.393. Sci. Eur. In another study, ultrasmall Au nanoparticles of sizes ranging from 2 to 15nm coated with tiopronin were evaluated for their localization and penetration into breast cancer cells, and it was found that accumulation of smaller nanoparticles was higher in tumor tissues in mice [104]. Am. Navya et al., Single step formation of biocompatible bimetallic alloy nanoparticles of gold and silver using isonicotinylhydrazide. 2(2), 85120 (2009), A. Accardo, G. Morelli, Review peptide-targeted liposomes for selective drug delivery: advantages and problematic issues. This increased circulation time can also lead to higher potency and specific antitumor activity. B Biointerfaces 111, 117123 (2013), S. Aryal, C.-M.J. Hu, L. Zhang, Polymercisplatin conjugate nanoparticles for acid-responsive drug delivery. Polym. Docetaxel-loaded galactosamine combined with polydopamine-modified nanoparticles synthesized from d-a-tocopherol polyethylene glycol 1000 succinate-poly(lactide) (Gal-pD-TPGS-PLA/NPs) were found to inhibit the growth of HepG2 cells more effectively than TPGS-PLA/NPs, pD-TPGS-PLA/NPs, and a clinically available docetaxel formulation (Taxotere). J. Yao Y, Zhou Y, Liu L, Xu Y, Chen Q, Wang Y, Wu S, Deng Y, Zhang J, Shao A. Drug Deliv. 519(1), 352364 (2017), Y. Zhao et al., Methotrexate nanoparticles prepared with codendrimer from polyamidoamine (PAMAM) and oligoethylene glycols (OEG) dendrons: antitumor efficacy in vitro and in vivo. Unable to load your collection due to an error, Unable to load your delegates due to an error. 58, 349364 (2017), Y. Peng et al., Codelivery of temozolomide and siRNA with polymeric nanocarrier for effective glioma treatment. Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology. Organic nanomaterials are promising candidates for the development of drug delivery systems. 2022 Mar 1;2(3):258-281. doi: 10.1021/acsbiomedchemau.2c00003. 17, 201209 (2015), A. Al Faraj, A.P. Nanotechnol. Chem. Navya, A. Kaphle, H.K. 16(4), 12731304 (2017), Y. Chi et al., Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models. Am. Small 11(44), 59195926 (2015), E. Niemel et al., Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells. Therefore, it is essential to improve new procedures for the diagnosis and treatment of BC. 10.20944/preprints202110.0407.v1, Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. It could also highlight a tumor's parameters and margins to enhance the precision of diagnostics. Sci. B Biointerfaces 168, 4349 (2018), A. Kavosi et al., The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer. Disclaimer. These nanocarriers were stable and their release was reported to be pH responsive. Further, we also summarize the current perspective, advantages, and challenges in clinical translation. Mater. The carbon spheres provided high drug loading capacity along with sustained release of drug under acidic pH, which is the normal tumor microenvironment. 529(1), 102115 (2017), J.N. Biomed. The results revealed that the decrease in bacterial cell conductivity due to cell wall rupture and massive cell death which appears in the. Mol. Angew. Alginate and chitosan coated single walled carbon nanotubes loaded with curcumin could target human lung adenocarcinoma (A549) cells, as shown in one recent report [203]. 30, 144154 (2016), M. Jin et al., Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes. Rev. Sci. 12, 77637776 (2017), Y. Li et al., Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis.